<![CDATA[Subacute Combined Degeneration]]> https://alpha.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Wed, 19 Feb 2025 10:10:49 +0000 <![CDATA[Subacute Combined Degeneration]]> https://alpha.eurekaselect.com https://alpha.eurekaselect.com <![CDATA[Neuroimaging Features of Acquired Metabolic and Toxic Encephalopathies]]>https://alpha.eurekaselect.comarticle/83198

Aims: This review aims to summarize the imaging features of a number of acquired metabolic and toxic encephalopathies.

Discussion: These conditions are not diagnosed easily. Imaging is very important in terms of diagnosis, assessment of treatment response and prediction of prognosis. Therefore, it is important for radiologists to know the imaging features of relatively frequent acquired metabolic and toxic encephalopathies.

Conclusion: Integration of clinical information with the MRI findings can help physicians in diagnosis and treatment of the underlying disease.]]> <![CDATA[Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis]]>https://alpha.eurekaselect.comarticle/81481

Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.]]> <![CDATA[Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction]]>https://alpha.eurekaselect.comarticle/63701

Methods: A PubMed search was conducted using the search words including, but not limited to: metformin, Major Depressive Disorder, type 2 diabetes mellitus, and cognitive dysfunction. All English language articles published from 1990 to July 2014 were reviewed.

Results: Extant preclinical and clinical data have been mixed, wherein both cognitive disruption and pro-cognitive effects have been reported with the administration of metformin. Sound mechanistic evidence supports metformin as a treatment; however, the heterogeneity of study designs has contributed to an inability to arrive at an unequivocal conclusion regarding metformin effects upon cognition.

Conclusion: Available evidence does not provide a robust signal for improvement in cognition in either mood disorder or T2DM samples. Notwithstanding, it is premature to label metformin as a “no-go” agent for further testing and development for cognitive dysfunction. A well designed, proof-of-concept trial of metformin investigating its possible cognitive effects in mood disorders is therefore warranted.]]> <![CDATA[ Epigenetics in Alzheimers Disease: a Focus on DNA Modifications]]>https://alpha.eurekaselect.comarticle/20500

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